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Getting started

Here’s a breakdown of the steps and support you can expect when getting started with Madrigal Patient Support®—from enrollment to receiving your medication. One important step: make sure you’ve enrolled! Our support begins as soon as you sign up—at no cost to you.

Enroll in Patient Support Learn more about the program
Learn more about: Prescription sent • Costs confirmed • Medicine ready • Refills • FAQs

Your new medication journey, step by step

1

Your prescription is sent to a specialty pharmacy

Your doctor or Madrigal Patient Support will send your Rezdiffra® (resmetirom) prescription to a specialty pharmacy.

Our specialty pharmacies include: AcariaHealth, Accredo, Amber, CenterWell, CVS Specialty, Optum, and Walgreens Specialty.

Did you know?

Specialty pharmacies involve a different process from retail pharmacies. Our team can help you understand the process and next steps.

2

Medication costs, coverage, and financial assistance are confirmed

Your insurance may require your doctor to send medical documents to cover your medication. This process is called prior authorization (PA).

Once coverage is confirmed, your specialty pharmacy can explain any out-of-pocket costs. Your Madrigal Patient Access Manager can notify you of financial assistance options that may be available to you.

Explore savings

If you have commercial insurance, you may be able to pay as little as $0 a month*.

*Eligibility rules apply. Offer not valid for patients enrolled in Medicare, Medicaid, or other federal or state healthcare programs. For program terms, conditions, and eligibility criteria, visit copay.rezdiffra.com.

3

Your medication is ready for delivery

Your specialty pharmacy or Madrigal Patient Support will call you to schedule your medication delivery. It's important that you confirm your shipping address.

Most patients typically receive their medication within about 30 days.

Keep in mind

The specialty pharmacy will not ship your medication until they confirm your shipping address. Be sure to answer or return any missed calls from your specialty pharmacy and Madrigal Patient Support.

4

It's time to refill your prescription

Your specialty pharmacy or Madrigal Patient Support will call you when it's time for a refill. It's important to answer the call to keep on track with your medicine.

Frequently asked questions

Madrigal Patient Support is here to help you navigate financial challenges and access your prescribed medicine. We’ll work with you to explore options based on your insurance and eligibility. To find out what support may be available to you, call Madrigal Patient Support at 1-877-219-7770, Monday – Friday, 8 AM – 8 PM ET.

Explore options

If you’ve been prescribed Rezdiffra® (resmetirom) by your doctor, your prescription will be delivered directly to your doorstep through a specialty pharmacy. The specialty pharmacy or Madrigal Patient Support will call you to review your prescription, confirm your insurance, and discuss financial assistance options. Once everything is verified, your medication is shipped straight to you.

Learn more

A specialty pharmacy stocks medications and treatments that are not typically found at your local retail pharmacy. They provide medications that typically require special handling or are for chronic or complex conditions. Specialty pharmacies ship your medication directly to you.

You’ll get a call from your specialty pharmacy or Madrigal Patient Support to schedule your delivery. Be sure to answer the call to avoid delays.

Most patients typically receive their medication within about 30 days.

A specialty pharmacy is different from your local retail pharmacy. Medicines from a specialty pharmacy are not picked up in person. Once your insurance coverage is approved, the specialty pharmacy will call you to arrange delivery to your home address.

Your Patient Access Manager can help you understand the specialty pharmacy process and what next steps to expect. You can call Madrigal Patient Support or your specialty pharmacy with any questions.

There is a limited network of specialty pharmacies that fulfill Rezdiffra® (resmetirom) prescriptions. Your insurance provider may determine which specialty pharmacy can fill your prescription. You can contact your doctor’s office to find out which specialty pharmacy is filling your prescription.

Have questions? Give us a call

1-877-219-7770

Monday – Friday, 8 AM – 8 PM ET

Spanish-speaking representatives available

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Indication and Important Safety Information

What is Rezdiffra?

Rezdiffra is a prescribed medicine used along with diet and exercise to treat adults with metabolic dysfunction-associated steatohepatitis (MASH) with moderate to advanced liver scarring (fibrosis), but not with cirrhosis of the liver.

This indication is approved based on improvement of MASH and liver scarring (fibrosis). There are ongoing studies to confirm the clinical benefit of Rezdiffra.

Before you take Rezdiffra, tell your healthcare provider about all of your medical conditions, including if you:

  • have any liver problems other than MASH.
  • have gallbladder problems or have been told you have gallbladder problems, including gallstones
  • are pregnant or plan to become pregnant. It is not known if Rezdiffra will harm your unborn baby.
    • A pregnancy safety study for women who take Rezdiffra during pregnancy collects information about the
      health of you and your baby. You or your healthcare provider can report your pregnancy by visiting https://pregnancyregistry.madrigalpharma.com/ or calling 1-800-905-0324.
  • are breastfeeding or plan to breastfeed. It is not known if Rezdiffra passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby if you take Rezdiffra.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

  • Rezdiffra and other medicines may affect each other, causing side effects. Rezdiffra may affect the way other medicines work, and other medicines may affect how Rezdiffra works.
  • Especially tell your healthcare provider if you take medicines that contain gemfibrozil to help lower your triglycerides because Rezdiffra is not recommended in patients taking these medicines.
  • Tell your healthcare provider if you are taking medicines such as clopidogrel to thin your blood or statin medicines to help lower your cholesterol.
  • Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.

What are the possible side effects of Rezdiffra?

Rezdiffra may cause serious side effects, including:

  • liver injury (hepatotoxicity). Stop taking Rezdiffra and call your healthcare provider right away if you develop the following signs or symptoms of hepatotoxicity: tiredness, nausea, vomiting, fever, rash, your skin or the white part of your eyes turns yellow (jaundice), or stomach pain/tenderness.
  • gallbladder problems. Gallbladder problems such as gallstones, or inflammation of the gallbladder, or inflammation of the pancreas from gallstones can occur with MASH and may occur if you take Rezdiffra. Call your healthcare provider right away if you develop any signs or symptoms of these conditions, including nausea, vomiting, fever, or pain in your stomach area (abdomen) that is severe and will not go away. The pain may be felt going from your abdomen to your back and the pain may happen with or without vomiting.

The most common side effects of Rezdiffra include diarrhea, nausea, itching, stomach pain, vomiting, dizziness, and constipation.

These are not all the possible side effects of Rezdiffra. For more information, ask your healthcare provider or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Madrigal Pharmaceuticals, Inc. at 1-800-905-0324.

Please see the full Prescribing Information, including Patient Information, for Rezdiffra.

Indication and Important Safety Information

What is Rezdiffra?

Rezdiffra is a prescribed medicine used along with diet and exercise to treat adults with metabolic dysfunction-associated steatohepatitis (MASH) with moderate to advanced liver scarring (fibrosis), but not with cirrhosis of the liver.

This indication is approved based on improvement of MASH and liver scarring (fibrosis). There are ongoing studies to confirm the clinical benefit of Rezdiffra.

Before you take Rezdiffra, tell your healthcare provider about all of your medical conditions, including if you:

  • have any liver problems other than MASH.
  • have gallbladder problems or have been told you have gallbladder problems, including gallstones
  • are pregnant or plan to become pregnant. It is not known if Rezdiffra will harm your unborn baby.
    • A pregnancy safety study for women who take Rezdiffra during pregnancy collects information about the
      health of you and your baby. You or your healthcare provider can report your pregnancy by visiting https://pregnancyregistry.madrigalpharma.com/ or calling 1-800-905-0324.
  • are breastfeeding or plan to breastfeed. It is not known if Rezdiffra passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby if you take Rezdiffra.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

  • Rezdiffra and other medicines may affect each other, causing side effects. Rezdiffra may affect the way other medicines work, and other medicines may affect how Rezdiffra works.
  • Especially tell your healthcare provider if you take medicines that contain gemfibrozil to help lower your triglycerides because Rezdiffra is not recommended in patients taking these medicines.
  • Tell your healthcare provider if you are taking medicines such as clopidogrel to thin your blood or statin medicines to help lower your cholesterol.
  • Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.

What are the possible side effects of Rezdiffra?

Rezdiffra may cause serious side effects, including:

  • liver injury (hepatotoxicity). Stop taking Rezdiffra and call your healthcare provider right away if you develop the following signs or symptoms of hepatotoxicity: tiredness, nausea, vomiting, fever, rash, your skin or the white part of your eyes turns yellow (jaundice), or stomach pain/tenderness.
  • gallbladder problems. Gallbladder problems such as gallstones, or inflammation of the gallbladder, or inflammation of the pancreas from gallstones can occur with MASH and may occur if you take Rezdiffra. Call your healthcare provider right away if you develop any signs or symptoms of these conditions, including nausea, vomiting, fever, or pain in your stomach area (abdomen) that is severe and will not go away. The pain may be felt going from your abdomen to your back and the pain may happen with or without vomiting.

The most common side effects of Rezdiffra include diarrhea, nausea, itching, stomach pain, vomiting, dizziness, and constipation.

These are not all the possible side effects of Rezdiffra. For more information, ask your healthcare provider or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Madrigal Pharmaceuticals, Inc. at 1-800-905-0324.

Please see the full Prescribing Information, including Patient Information, for Rezdiffra.