Actor portrayal

Program overview

At Madrigal Patient Support®, we’re dedicated to offering comprehensive treatment support for patients prescribed Rezdiffra® (resmetirom).

Actor portrayal

Our program is specially designed for you

We can help you understand your insurance coverage, your condition, and your Rezdiffra® (resmetirom) medication.

Our program is designed to help with:

Financial assistance options that may help you manage the costs of your medicine

Comprehensive support to answer your questions and guide you through treatment as prescribed

Dedicated team of Nurse Navigators who will answer your questions and check in (at your preference)

Actor portrayal

We’re here to help you navigate your treatment with confidence

With Madrigal Patient Support, a dedicated team will be by your side every step of the way.

Here are some of the ways we can support you

Check-ins at your desired pace

We'll reach out when you prefer, to see how you're doing and answer questions about your treatment

Insurance and coverage support

Guidance if your insurance changes or if you need help exploring coverage options

Personalized connections and helpful resources

Connections to Nurse Navigators, Patient Ambassadors, and other helpful resources

From my first call, Madrigal Patient Support made everything easier. They presented options for financial support and connected me with the one that worked. They’ve also been great about nursing support, helping me when I have questions.

Suzanne Rezdiffra Real Voices™ Ambassador
Patient Ambassadors are sponsored by Madrigal Pharmaceuticals.

Frequently asked questions

If you’ve been prescribed Rezdiffra® (resmetirom), you likely have questions. Madrigal Patient Support is here to help you start and stay on track throughout your Rezdiffra treatment journey. Madrigal Patient Support can help enrolled patients:

  • Find the specialty pharmacy that can fill your Rezdiffra prescription
  • Verify your insurance coverage for Rezdiffra
  • Identify possible financial assistance options you may be eligible for
  • Connect you with a Nurse Navigator who can provide education and support throughout your treatment journey

Our support begins when you sign up—at no cost to you.

You or your doctor can enroll you in the program when you begin treatment with Rezdiffra® (resmetirom). If your doctor initiates the process, you will need to sign a Patient Authorization Form to allow the program to assist you. If you prefer, you can provide authorization electronically without going through your doctor’s office.

When you provide your authorization, you can receive helpful resources and support from Madrigal Patient Support.

Ready to enroll?

Get started now Learn more about enrolling

If your doctor starts your enrollment, you’ll be asked to sign a Patient Authorization Form. This allows your doctor to share your information with Madrigal Patient Support, so we can support you with treatment access support.

When you provide your authorization, you can receive helpful resources and support from Madrigal Patient Support.

Our Nurse Navigator team provides education about your condition and your prescribed medicine. Your Nurse Navigator can explain how it works, what to expect, and answer any questions you might have.

Keep in mind: Your doctor is the best source of information for questions about your health and treatment.

Actor portrayal on couch with tablet Actor portrayal

Our support begins when you sign up

At no cost to you.

Enroll in Patient Support

Have questions? Give us a call

1-877-219-7770

Monday – Friday, 8 AM – 8 PM ET

Spanish-speaking representatives available

Back to top

Indication and Important Safety Information

What is Rezdiffra?

Rezdiffra is a prescribed medicine used along with diet and exercise to treat adults with metabolic dysfunction-associated steatohepatitis (MASH) with moderate to advanced liver scarring (fibrosis), but not with cirrhosis of the liver.

This indication is approved based on improvement of MASH and liver scarring (fibrosis). There are ongoing studies to confirm the clinical benefit of Rezdiffra.

Before you take Rezdiffra, tell your healthcare provider about all of your medical conditions, including if you:

  • have any liver problems other than MASH.
  • have gallbladder problems or have been told you have gallbladder problems, including gallstones
  • are pregnant or plan to become pregnant. It is not known if Rezdiffra will harm your unborn baby.
    • A pregnancy safety study for women who take Rezdiffra during pregnancy collects information about the
      health of you and your baby. You or your healthcare provider can report your pregnancy by visiting https://pregnancyregistry.madrigalpharma.com/ or calling 1-800-905-0324.
  • are breastfeeding or plan to breastfeed. It is not known if Rezdiffra passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby if you take Rezdiffra.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

  • Rezdiffra and other medicines may affect each other, causing side effects. Rezdiffra may affect the way other medicines work, and other medicines may affect how Rezdiffra works.
  • Especially tell your healthcare provider if you take medicines that contain gemfibrozil to help lower your triglycerides because Rezdiffra is not recommended in patients taking these medicines.
  • Tell your healthcare provider if you are taking medicines such as clopidogrel to thin your blood or statin medicines to help lower your cholesterol.
  • Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.

What are the possible side effects of Rezdiffra?

Rezdiffra may cause serious side effects, including:

  • liver injury (hepatotoxicity). Stop taking Rezdiffra and call your healthcare provider right away if you develop the following signs or symptoms of hepatotoxicity: tiredness, nausea, vomiting, fever, rash, your skin or the white part of your eyes turns yellow (jaundice), or stomach pain/tenderness.
  • gallbladder problems. Gallbladder problems such as gallstones, or inflammation of the gallbladder, or inflammation of the pancreas from gallstones can occur with MASH and may occur if you take Rezdiffra. Call your healthcare provider right away if you develop any signs or symptoms of these conditions, including nausea, vomiting, fever, or pain in your stomach area (abdomen) that is severe and will not go away. The pain may be felt going from your abdomen to your back and the pain may happen with or without vomiting.

The most common side effects of Rezdiffra include diarrhea, nausea, itching, stomach pain, vomiting, dizziness, and constipation.

These are not all the possible side effects of Rezdiffra. For more information, ask your healthcare provider or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Madrigal Pharmaceuticals, Inc. at 1-800-905-0324.

Please see the full Prescribing Information, including Patient Information, for Rezdiffra.

Indication and Important Safety Information

What is Rezdiffra?

Rezdiffra is a prescribed medicine used along with diet and exercise to treat adults with metabolic dysfunction-associated steatohepatitis (MASH) with moderate to advanced liver scarring (fibrosis), but not with cirrhosis of the liver.

This indication is approved based on improvement of MASH and liver scarring (fibrosis). There are ongoing studies to confirm the clinical benefit of Rezdiffra.

Before you take Rezdiffra, tell your healthcare provider about all of your medical conditions, including if you:

  • have any liver problems other than MASH.
  • have gallbladder problems or have been told you have gallbladder problems, including gallstones
  • are pregnant or plan to become pregnant. It is not known if Rezdiffra will harm your unborn baby.
    • A pregnancy safety study for women who take Rezdiffra during pregnancy collects information about the
      health of you and your baby. You or your healthcare provider can report your pregnancy by visiting https://pregnancyregistry.madrigalpharma.com/ or calling 1-800-905-0324.
  • are breastfeeding or plan to breastfeed. It is not known if Rezdiffra passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby if you take Rezdiffra.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

  • Rezdiffra and other medicines may affect each other, causing side effects. Rezdiffra may affect the way other medicines work, and other medicines may affect how Rezdiffra works.
  • Especially tell your healthcare provider if you take medicines that contain gemfibrozil to help lower your triglycerides because Rezdiffra is not recommended in patients taking these medicines.
  • Tell your healthcare provider if you are taking medicines such as clopidogrel to thin your blood or statin medicines to help lower your cholesterol.
  • Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.

What are the possible side effects of Rezdiffra?

Rezdiffra may cause serious side effects, including:

  • liver injury (hepatotoxicity). Stop taking Rezdiffra and call your healthcare provider right away if you develop the following signs or symptoms of hepatotoxicity: tiredness, nausea, vomiting, fever, rash, your skin or the white part of your eyes turns yellow (jaundice), or stomach pain/tenderness.
  • gallbladder problems. Gallbladder problems such as gallstones, or inflammation of the gallbladder, or inflammation of the pancreas from gallstones can occur with MASH and may occur if you take Rezdiffra. Call your healthcare provider right away if you develop any signs or symptoms of these conditions, including nausea, vomiting, fever, or pain in your stomach area (abdomen) that is severe and will not go away. The pain may be felt going from your abdomen to your back and the pain may happen with or without vomiting.

The most common side effects of Rezdiffra include diarrhea, nausea, itching, stomach pain, vomiting, dizziness, and constipation.

These are not all the possible side effects of Rezdiffra. For more information, ask your healthcare provider or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Madrigal Pharmaceuticals, Inc. at 1-800-905-0324.

Please see the full Prescribing Information, including Patient Information, for Rezdiffra.